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An epigenetic switch: from senescent melanocytes to malignant melanoma (and back)
File(s)
Wagnerpreview3.pdf (725.72 KB)
Accepted version
Author(s)
Wagner, Verena
Gil, J
Type
Journal Article
Abstract
Oncogene-induced senescence is an important barrier during melanomagenesis. In this issue of Cancer Cell, Yu et al. show how elevated expression of structurally unrelated H3K9 demethylases disables senescence and constitutes a liability that can be exploited to restore senescence in melanoma by pharmacological inhibition of these epigenetic regulators.
Date Issued
2018-02-12
Date Acceptance
2018-01-22
Citation
Cancer Cell, 2018, 33 (2), pp.162-163
URI
DOI
ISSN
1535-6108
Publisher
Elsevier (Cell Press)
Start Page
162
End Page
163
Journal / Book Title
Cancer Cell
Volume
33
Issue
2
Copyright Statement
© 2018 Elsevier Inc. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
2019-02-12
Subjects
1112 Oncology And Carcinogenesis
1109 Neurosciences
Oncology & Carcinogenesis
Publication Status
Published