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  5. The FLASH effect-an evaluation of preclinical studies of ultra-high dose rate radiotherapy
 
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The FLASH effect-an evaluation of preclinical studies of ultra-high dose rate radiotherapy
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The FLASH effect-an evaluation of preclinical studies of ultra-high dose rate radiotherapy.pdf (3.3 MB)
Published version
Author(s)
McGarrigle, Josie May
Long, Kenneth Richard
Prezado, Yolanda
Type
Journal Article
Abstract
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise healthy tissues. The FLASH effect is the observation that treatment delivered at an ultra-high dose rate is able to reduce adverse toxicities present at conventional dose rates. While this novel technique may provide a turning point for clinical practice, the exact mechanisms underlying the causes or influences of the FLASH effect are not fully understood. The study presented here uses data collected from 41 experimental investigations (published before March 2024) of the FLASH effect. Searchable databases were constructed to contain the outcomes of the various experiments in addition to values of beam parameters that may have a bearing on the FLASH effect. An in-depth review of the impact of the key beam parameters on the results of the experiments was carried out. Correlations between parameter values and experimental outcomes were studied. Pulse Dose Rate had positive correlations with almost all end points, suggesting viability of FLASH-RT as a new modality of radiotherapy. The collective results of this systematic review study suggest that beam parameter qualities from both FLASH and conventional radiotherapy can be valuable for tissue sparing and effective tumour treatment.
Date Issued
2024-04-22
Date Acceptance
2024-03-20
Citation
Frontiers in Oncology, 2024, 14
URI
http://hdl.handle.net/10044/1/111653
DOI
https://www.dx.doi.org/10.3389/fonc.2024.1340190
ISSN
2234-943X
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Oncology
Volume
14
Copyright Statement
© 2024 McGarrigle, Long and Prezado. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
https://creativecommons.org/licenses/by/4.0/
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38711846
Subjects
FLASH
FLASH-RT
normal-tissue sparing
radiation - adverse effects
radiotherapy
therapeutic index
ultra-high dose rate
ultra-high dose rate irradiation
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
1340190
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