Myocardial Architecture, Mechanics, and Fibrosis in Congenital Heart Disease
File(s)
Author(s)
Type
Journal Article
Abstract
Congenital heart disease (CHD) is the most common category of birth defect, affecting
1% of the population and requiring cardiovascular surgery in the first months of life
in many patients. Due to advances in congenital cardiovascular surgery and patient
management, most children with CHD now survive into adulthood. However, residual
and postoperative defects are common resulting in abnormal hemodynamics, which
may interact further with scar formation related to surgical procedures. Cardiovascular
magnetic resonance (CMR) has become an important diagnostic imaging modality in
the long-term management of CHD patients. It is the gold standard technique to assess
ventricular volumes and systolic function. Besides this, advanced CMR techniques allow
the acquisition of more detailed information about myocardial architecture, ventricular
mechanics, and fibrosis. The left ventricle (LV) and right ventricle have unique myocardial
architecture that underpins their mechanics; however, this becomes disorganized under
conditions of volume and pressure overload. CMR diffusion tensor imaging is able to
interrogate non-invasively the principal alignments of microstructures in the left ventricular
wall. Myocardial tissue tagging (displacement encoding using stimulated echoes) and
feature tracking are CMR techniques that can be used to examine the deformation and
strain of the myocardium in CHD, whereas 3D feature tracking can assess the twisting
motion of the LV chamber. Late gadolinium enhancement imaging and more recently T1
mapping can help in detecting fibrotic myocardial changes and evolve our understanding
of the pathophysiology of CHD patients. This review not only gives an overview about
available or emerging CMR techniques for assessing myocardial mechanics and fibrosis
but it also describes their clinical value and how they can be used to detect abnormalities
in myocardial architecture and mechanics in CHD patients.
1% of the population and requiring cardiovascular surgery in the first months of life
in many patients. Due to advances in congenital cardiovascular surgery and patient
management, most children with CHD now survive into adulthood. However, residual
and postoperative defects are common resulting in abnormal hemodynamics, which
may interact further with scar formation related to surgical procedures. Cardiovascular
magnetic resonance (CMR) has become an important diagnostic imaging modality in
the long-term management of CHD patients. It is the gold standard technique to assess
ventricular volumes and systolic function. Besides this, advanced CMR techniques allow
the acquisition of more detailed information about myocardial architecture, ventricular
mechanics, and fibrosis. The left ventricle (LV) and right ventricle have unique myocardial
architecture that underpins their mechanics; however, this becomes disorganized under
conditions of volume and pressure overload. CMR diffusion tensor imaging is able to
interrogate non-invasively the principal alignments of microstructures in the left ventricular
wall. Myocardial tissue tagging (displacement encoding using stimulated echoes) and
feature tracking are CMR techniques that can be used to examine the deformation and
strain of the myocardium in CHD, whereas 3D feature tracking can assess the twisting
motion of the LV chamber. Late gadolinium enhancement imaging and more recently T1
mapping can help in detecting fibrotic myocardial changes and evolve our understanding
of the pathophysiology of CHD patients. This review not only gives an overview about
available or emerging CMR techniques for assessing myocardial mechanics and fibrosis
but it also describes their clinical value and how they can be used to detect abnormalities
in myocardial architecture and mechanics in CHD patients.
Date Issued
2017-05-23
Date Acceptance
2017-04-28
Citation
Frontiers in Cardiovascular Medicine, 2017, 4
ISSN
2297-055X
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Cardiovascular Medicine
Volume
4
Copyright Statement
© 2017 Ghonim, Voges, Gatehouse, Keegan, Gatzoulis, Kilner and BabuNarayan.
This is an open-access article distributed under the terms of the Creative
Commons Attribution License (CC BY). The use, distribution or reproduction in
other forums is permitted, provided the original author(s) or licensor are credited
and that the original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which does not
comply with these terms.
This is an open-access article distributed under the terms of the Creative
Commons Attribution License (CC BY). The use, distribution or reproduction in
other forums is permitted, provided the original author(s) or licensor are credited
and that the original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which does not
comply with these terms.
License URL
Sponsor
British Heart Foundation
Grant Number
FS/11/38/28864
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
cardiology
congenital heart disease
cardiovascular magnetic resonance imaging
late gadolinium enhancement cardiovascular magnetic resonance
myocardial strain
fibrosis
diffusion tensor imaging
CARDIOVASCULAR MAGNETIC-RESONANCE
SYSTEMIC RIGHT VENTRICLE
LATE GADOLINIUM ENHANCEMENT
OUTFLOW TRACT OBSTRUCTION
SEVERE AORTIC-STENOSIS
CANINE LEFT-VENTRICLE
REPAIRED TETRALOGY
FEATURE TRACKING
FIBER-ORIENTATION
GREAT-ARTERIES
Publication Status
Published
Article Number
30