Diverse structural approaches to haem appropriation by pathogenic bacteria
File(s)
Published version
Author(s)
Hare, SA
Type
Journal Article
Abstract
The critical need for iron presents a challenge for pathogenic bacteria that must survive in an environment bereft of accessible iron due to a natural low bioavailability and their host's nutritional immunity. Appropriating haem, either direct from host haemoproteins or by secreting haem-scavenging haemophores, is one way pathogenic bacteria can overcome this challenge. After capturing their target, haem appropriation systems must remove haem from a high-affinity binding site (on the host haemoprotein or bacterial haemophore) and transfer it to a binding site of lower affinity on a bacterial receptor. Structural information is now available to show how, using a combination of induced structural changes and steric clashes, bacteria are able to extract haem from haemophores, haemopexin and haemoglobin. This review focuses on structural descriptions of these bacterial haem acquisition systems, summarising how they bind haem and their target haemoproteins with particularly emphasis on the mechanism of haem extraction.
Date Issued
2017-01-24
Date Acceptance
2017-01-23
Citation
Biochimica et Biophysica Acta - Proteins and Proteomics, 2017, 1865 (4), pp.422-433
ISSN
1570-9639
Publisher
Elsevier
Start Page
422
End Page
433
Journal / Book Title
Biochimica et Biophysica Acta - Proteins and Proteomics
Volume
1865
Issue
4
Copyright Statement
© 2017 The Author. Published by Elsevier B.V. This is an open access article under the CC BY license (http://
creativecommons.org/licenses/by/4.0/).
creativecommons.org/licenses/by/4.0/).
Sponsor
Medical Research Council (MRC)
Grant Number
G1100332
Subjects
Bacteria
Heme
Hemoprotein
Host-pathogen interaction
Iron
Nutritional immunity
Biochemistry & Molecular Biology
06 Biological Sciences
02 Physical Sciences
Publication Status
Published