A history of hypertension has been associated with increased risk of endometrial cancer in
several studies, but the results have not been
consistent. We conducted a systematic review
and meta-analysis of case-control and cohort
studies to clarify the association between
hypertension and endometrial cancer risk. P
ubMed and Embase databases were searched up
to 27
th
of February 2016. Prospective and case
-control studies which reported adjusted
relative risk estimates and 95% confidence intervals of endometrial cancer associated with a
hypertension diagnosis were included. Summary
relative risks were estimated using a random
effects model. Twenty case-control studies a
nd 6 cohort studies were included. The summary
RR was 1.61 (95% CI: 1.41-1.85, I
2
=86%) for all studies, 1.73 (95% CI: 1.45-2.06, I
2
=89%)
for case-control studies and 1.32 (95% CI: 1.12-1.56, I
2
=47%) for cohort studies.
The
association between hypertension and endometrial cancer was weaker, but still significant,
among studies with adjustment for smoking, BMI, oral contraceptive use, and parity,
compared to studies without such adjustment.
This meta-analysis suggest an increased risk of
endometrial cancer among patients with hypertension, however, further studies with more
comprehensive adjustments for confounders are warranted to clarify the association.