Advanced risk prediction for aortic dissection patients using imaging-based computational flow analysis
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Published version
Author(s)
Zhu, Yu
Xu, Xiao Yun
Rosendahl, Ulrich
Pepper, John
Mirsadraee, Saeed
Type
Journal Article
Abstract
Patients with either a repaired or medically managed aortic dissection have varying degrees of risk of developing late complications. High-risk patients would benefit from earlier intervention to improve their long-term survival. Currently serial imaging is used for risk stratification, which is not always reliable. On the other hand, understanding aortic haemodynamics within a dissection is essential to fully evaluate the disease and predict how it may progress. In recent decades, computational fluid dynamics (CFD) has been extensively applied to simulate complex haemodynamics within aortic diseases, and more recently, four-dimensional (4D)-flow magnetic resonance imaging (MRI) techniques have been developed for in vivo haemodynamic measurement. This paper presents a comprehensive review on the application of image-based CFD simulations and 4D-flow MRI analysis for risk prediction in aortic dissection. The key steps involved in patient-specific CFD analyses are demonstrated. Finally, we propose a workflow incorporating computational modelling for personalised assessment to aid in risk stratification and treatment decision-making.
Date Issued
2023-03-01
Date Acceptance
2022-12-02
Citation
Clinical Radiology, 2023, 78 (3), pp.e155-e165
ISSN
0009-9260
Publisher
Elsevier
Start Page
e155
End Page
e165
Journal / Book Title
Clinical Radiology
Volume
78
Issue
3
Copyright Statement
© 2022 Published by Elsevier Ltd on behalf of The Royal College of Radiologists. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Publication Status
Published
Date Publish Online
2022-12-23