Immunological consequences of strain variation within the Mycobacterium tuberculosis complex
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally, making it one of the leading causes of death due to an infectious disease. TB is caused by members of the Mycobacterium tuberculosis complex (MTBC), with human disease resulting from infection by M. tuberculosis sensu stricto and M. africanum. Recent progress in genotyping techniques, in particular the increasing availability of whole genome sequence data, has revealed previously under appreciated levels of genetic diversity within the MTBC. Several studies have shown that this genetic diversity may translate into differences in TB transmission, clinical manifestations of disease, and host immune responses. This suggests the existence of MTBC genotype-dependent host–pathogen interactions which may influence the outcome of infection and progression of disease. In this review, we highlight the studies demonstrating differences in innate and adaptive immunological outcomes consequent on MTBC genetic diversity, and discuss how these differences in immune response might influence the development of TB vaccines, diagnostics and new therapies.
Date Issued
2017-02-24
Date Acceptance
2017-01-31
Citation
EUROPEAN JOURNAL OF IMMUNOLOGY, 2017, 47 (3), pp.432-445
ISSN
0014-2980
Publisher
WILEY
Start Page
432
End Page
445
Journal / Book Title
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume
47
Issue
3
Copyright Statement
© 2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor
Wellcome Trust
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000397564400002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
104803/Z/14/ZR
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Adaptive and innate immunity
Genetic diversity
Host response
Mycobacterium tuberculosis complex
Translational implications
MANNOSE-BINDING LECTIN
PULMONARY TUBERCULOSIS
HUMAN MACROPHAGES
BEIJING GENOTYPE
CLINICAL STRAINS
IMMUNE-RESPONSE
DENDRITIC CELLS
VACCINE EFFICACY
SOUTH-AFRICA
CAPE-TOWN
1107 Immunology
Publication Status
Published