HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection
File(s)
Published version
Author(s)
Bangham, Charles RM
Cook, Lucy B
Melamed, Anat
Type
Journal Article
Abstract
Human T lymphotropic virus type 1 (HTLV-1) causes a range of chronic inflammatory diseases and an aggressive malignancy of T lymphocytes known as adult T-cell leukaemia/lymphoma (ATLL). A cardinal feature of HTLV-1 infection is the presence of expanded clones of HTLV-1-infected T cells, which may persist for decades. A high viral burden (proviral load) is associated with both the inflammatory and malignant diseases caused by HTLV-1, and it has been believed that the oligoclonal expansion of infected cells predisposes to these diseases. However, it is not understood what regulates the clonality of HTLV-1 in vivo, that is, the number and abundance of HTLV-1-infected T cell clones. We review recent advances in the understanding of HTLV-1 infection and disease that have come from high-throughput quantification and analysis of HTLV-1 clonality in natural infection.
Date Issued
2014-06-01
Date Acceptance
2013-12-01
Citation
Seminars in Cancer Biology, 2014, 26, pp.89-98
ISSN
1044-579X
Publisher
Elsevier
Start Page
89
End Page
98
Journal / Book Title
Seminars in Cancer Biology
Volume
26
Copyright Statement
© 2013 Elsevier Ltd. All rights reserved. This is an open-access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use, distribution and
reproduction in any medium, provided the original author and source are credited.
Commons Attribution License, which permits unrestricted use, distribution and
reproduction in any medium, provided the original author and source are credited.
License URL
Sponsor
Medical Research Council (MRC)
Wellcome Trust
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338409700011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Grant Number
MR/K019090/1
100291/Z/12/Z
Subjects
ASYMPTOMATIC CARRIERS
CIRCULATING CELLS
Clonality
COMBINATION CHEMOTHERAPY
DENDRITIC CELLS
GENE-EXPRESSION
High-throughput sequencing
HTLV-1
Integration
INTERFERON-ALPHA
Leukaemia
Life Sciences & Biomedicine
Lymphoma
Oncology
Persistent infection
PROVIRAL LOAD
RETROVIRAL INTEGRATION
Retrovirus
Science & Technology
TROPICAL SPASTIC PARAPARESIS
VIRUS-TYPE-I
Publication Status
Published
Date Publish Online
2013-12-06