A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis
File(s)Nucl. Acids Res.-2016-Fletcher-nar-gkw938.pdf (2.87 MB)
Published version
Author(s)
Fletcher, CE
Godfrey, JD
Shibakawa, A
Bushell, M
Bevan, CL
Type
Journal Article
Abstract
Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3ß as a important modulator of miR biogenesis at Microprocessor level. Repression of GSK3ß activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed pri-miRs and reduction of mature pri-miRs without altering levels or cellular locations of miR biogenesis proteins...
Date Issued
2017-03-17
Date Acceptance
2016-10-19
Citation
Nucleic Acid Research, 2017, 45 (5), pp.2809-2828
ISSN
2159-3345
Publisher
Oxford University Press
Start Page
2809
End Page
2828
Journal / Book Title
Nucleic Acid Research
Volume
45
Issue
5
Copyright Statement
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Cancer Research UK
Wellcome Trust
Rosetrees Trust
Prostate Cancer UK
Prostate Cancer Foundation
Grant Number
12196
097816/Z/11/A
N/A
DCSJDBAAJ
20160119
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
GLYCOGEN-SYNTHASE KINASE-3
PROSTATE-CANCER
NUCLEAR-LOCALIZATION
IN-VITRO
CELLS
PHOSPHORYLATION
INHIBITION
3-BETA
PROLIFERATION
ACTIVATION
05 Environmental Sciences
06 Biological Sciences
08 Information And Computing Sciences
Developmental Biology
Publication Status
Published
Date Publish Online
2016-10-23