Modernising orodispersible film characterisation to improve palatability and acceptability using a toolbox of techniques
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Orodispersible films (ODFs) have been widely used in paediatric, geriatric and dysphagic patients due to ease of administration and precise and flexible dose adjustments. ODF fabrication has seen significant advancements with the move towards more technologically advanced production methods. The acceptability of ODFs is dependent upon film composition and process of formation, which affects disintegration, taste, texture and mouthfeel. There is currently a lack of testing to accurately assess ODFs for these important acceptability sensory perceptions. This study produced four ODFs formed of polyvinyl alcohol and sodium carboxymethylcellulose using 3D printing. These were assessed using three in vitro methods: Petri dish and oral cavity model (OCM) methods for disintegration and bio-tribology for disintegration and oral perception. Increasing polymer molecular weight (MW) exponentially increased disintegration time in the Petri dish and OCM methods. Higher MW films adhered to the OCM upper palate. Bio-tribology analysis showed that films of higher MW disintegrated quickest and had lower coefficient of friction, perhaps demonstrating good oral perception but also stickiness, with higher viscosity. These techniques, part of a toolbox, may enable formulators to design, test and reformulate ODFs that both disintegrate rapidly and may be better perceived when consumed, improving overall treatment acceptability.
Date Issued
2022-04-01
Date Acceptance
2022-03-28
Citation
Pharmaceutics, 2022, 14 (4)
ISSN
1999-4923
Publisher
MDPI AG
Journal / Book Title
Pharmaceutics
Volume
14
Issue
4
Copyright Statement
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35456566
PII: pharmaceutics14040732
Subjects
3D printing
acceptability
ATTRIBUTES
bio-tribology
COEFFICIENT
DISINTEGRATION
disintegration testing
DRUG-DELIVERY
FRICTION
INFANTS
Life Sciences & Biomedicine
mouthfeel
orodispersible films
Pharmacology & Pharmacy
POLYMERS
Science & Technology
TRIBOLOGY
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
732
Date Publish Online
2022-03-29