A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis
File(s)GarckeLNS17accepted.pdf (2.32 MB)
Accepted version
Author(s)
Garcke, H
Lam, KF
Nurnberg, R
Sitka, E
Type
Journal Article
Abstract
We derive a Cahn–Hilliard–Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. A multitude of phenomena such as nutrient diffusion and consumption, angiogenesis, hypoxia, blood vessel growth, and inhibition by toxic agents, which are released for example by the necrotic cells, are included. A new feature of the modelling approach is that a volume-averaged velocity is used, which dramatically simplifies the resulting equations. With the help of formally matched asymptotic analysis we develop new sharp interface models. Finite element numerical computations are performed and in particular the effects of necrosis on tumour growth are investigated numerically. In particular, for certain modelling choices, we obtain some form of focal and patchy necrotic growth that have been observed in experiments.
Date Issued
2018-03-01
Date Acceptance
2017-10-13
Citation
Mathematical Models and Methods in Applied Sciences (M3AS), 2018, 28 (3), pp.525-577
ISSN
0218-2025
Publisher
World Scientific Publishing
Start Page
525
End Page
577
Journal / Book Title
Mathematical Models and Methods in Applied Sciences (M3AS)
Volume
28
Issue
3
Copyright Statement
© World Scientific Publishing Company
Subjects
Science & Technology
Physical Sciences
Mathematics, Applied
Mathematics
Multiphase tumour growth
phase-field model
Darcy flow
necrosis
cellular adhesion
matched asymptotic expansions
finite element computations
NONLINEAR SIMULATION
NUMERICAL SIMULATIONS
MATHEMATICAL-MODEL
CELL
INVASION
VASCULARIZATION
DISCRETIZATION
CARCINOMA
TISSUES
SYSTEMS
math.AP
math.AP
q-bio.TO
92B05, 35K57, 35R35, 65M60
0102 Applied Mathematics
0103 Numerical and Computational Mathematics
Applied Mathematics
Publication Status
Published
Date Publish Online
2018-01-02