Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
File(s)
Published version
Author(s)
Franco Filho, Luciano Chaves
Barata, Rafael Ribeiro
Coelho, Mônica Silva
Cardoso, Jedson Ferreira
Lemos, Poliana da Silva
Type
Journal Article
Abstract
The existence of sylvatic transmission of dengue virus in communities of neotropical bats remains uncertain. In this work we present a near-complete genome of dengue virus serotype 4 obtained from the brain sample of a bat from Platyrrhinus helleri specie collected in the Brazilian Amazon region. The presence of the virus in the brain sample may indicate a possible tropism for the central nervous system in bats, which may justify negative results in previous studies that focused on analysis of other tissues, such as liver and spleen. Besides the duration of dengue virus circulation in the Americas (circa 40 years) may be too short for an implementation of a sylvatic dengue virus cycle. Our findings suggest that continued monitoring is needed to confirm with the neotropical bats could potentially act as a natural reservoir of dengue in the region.
Date Issued
2023-04
Date Acceptance
2023-01-25
Citation
Infection, Genetics and Evolution, 2023, 109, pp.1-5
ISSN
1567-1348
Publisher
Elsevier
Start Page
1
End Page
5
Journal / Book Title
Infection, Genetics and Evolution
Volume
109
Copyright Statement
1567-1348/© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36764633
PII: S1567-1348(23)00005-9
Subjects
Animals
Brain
Brazil
Chiroptera
Dengue
Dengue Virus
Serogroup
Arboviruses
Chiroptera
Dengue virus
High-throughput nucleotide sequencing
Publication Status
Published
Coverage Spatial
Netherlands
Article Number
105407
Date Publish Online
2023-02-09