Binding antibody levels to vaccine (HPV6/11/16/18) and non-vaccine (HPV31/33/45/52/58) HPV antigens up to 7 years following immunization with either Cervarix® or Gardasil® vaccine
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Human Papillomavirus (HPV) bivalent (Cervarix®) and quadrivalent (Gardasil®) vaccines demonstrate robust efficacy against vaccine types and cross-protection against related non-vaccine types. Here we evaluate the breadth, magnitude and durability of the vaccine-induced antibody response against vaccine (HPV6/11/16/18) and non-vaccine (HPV31/33/45/52/58) type antigens up to 7 years following vaccination of 12-15 year old girls in a three dose schedule and contrast these data with the levels of antibody typically seen in natural infection. Vaccine-type antibody levels waned over the 7-year follow up period but remained at least an order of magnitude above the typical antibody levels elicited by natural infection. Seropositivity to non-vaccine types remained high 7 years after initial vaccination, but antibody levels approached those typically generated following natural infection. Empirical data on the breadth, magnitude, specificity and durability of the immune response elicited by the HPV vaccines contribute to improving the evidence base supporting this important public health intervention.
Date Issued
2022-02-23
Date Acceptance
2022-01-20
Citation
Vaccine, 2022, 40 (9), pp.1198-1202
ISSN
0264-410X
Publisher
Elsevier
Start Page
1198
End Page
1202
Journal / Book Title
Vaccine
Volume
40
Issue
9
Copyright Statement
Crown Copyright © 2022 Published by Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35115194
PII: S0264-410X(22)00075-5
Subjects
Antibody
Durability
Human papillomavirus
Vaccine
Publication Status
Published
Coverage Spatial
Netherlands
Date Publish Online
2022-02-01