Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual’s complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and characterization. The accuracy of CCTA for quantifying stenosis and atherosclerosis has been validated in numerous multicentre studies and has shown consistent incremental prognostic value for MACE over the clinical risk spectrum in different populations. Serial CCTA studies have advanced our understanding of vascular biology and atherosclerotic disease progression. The direct disease visualization of CCTA has the potential to be used synergistically with indirect markers of risk to significantly improve prevention of MACE, pending large-scale randomized evaluation.
Date Issued
2024-05-21
Date Acceptance
2024-03-13
Citation
European Heart Journal, 2024, 45 (20), pp.1783-1800
ISSN
0195-668X
Publisher
Oxford University Press
Start Page
1783
End Page
1800
Journal / Book Title
European Heart Journal
Volume
45
Issue
20
Copyright Statement
© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38606889
PII: 7644662
Subjects
ALL-CAUSE MORTALITY
ARTERY-DISEASE
Atherosclerotic cardiovascular disease
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
CLINICAL-OUTCOMES
Coronary artery disease
Coronary computed tomography angiography
CT ANGIOGRAPHY
FRACTIONAL FLOW RESERVE
INTRAVASCULAR ULTRASOUND
Life Sciences & Biomedicine
Major adverse cardiovascular events
MYOCARDIAL-INFARCTION
PLAQUE BURDEN
Prevention
PROGNOSTIC VALUE
Science & Technology
STABLE CHEST-PAIN
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2024-04-12