A Fokker-Planck approach to the study of robustness in gene expression
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Published version
Author(s)
Degond, Pierre
Herda, Maxime
Mirrahimi, Sepideh
Type
Journal Article
Abstract
We study several Fokker-Planck equations arising from a stochastic chemical kinetic system modeling a gene regulatory network in biology. The densities solving the Fokker-Planck equations describe the joint distribution of the mRNA and μRNA content in a cell. We provide theoretical and numerical evidence that the robustness of the gene expression is increased in the presence of μRNA. At the mathematical level, increased robustness shows in a smaller coefficient of variation of the marginal density of the mRNA in the presence of μRNA. These results follow from explicit formulas for solutions. Moreover, thanks to dimensional analyses and numerical simulations we provide qualitative insight into the role of each parameter in the model. As the increase of gene expression level comes from the underlying stochasticity in the models, we eventually discuss the choice of noise in our models and its influence on our results.
Date Issued
2020-09-24
Date Acceptance
2020-09-15
Citation
Mathematical Biosciences and Engineering, 2020, 17 (6), pp.6459-6486
ISSN
1547-1063
Publisher
American Institute of Mathematical Sciences (AIMS)
Start Page
6459
End Page
6486
Journal / Book Title
Mathematical Biosciences and Engineering
Volume
17
Issue
6
Copyright Statement
© 2020 the Author(s), licensee AIMS Press. This
is an open access article distributed under the
terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0)
is an open access article distributed under the
terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0)
License URL
Sponsor
The Royal Society
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Grant Number
WM130048
EP/M006883/1
EP/N014529/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Mathematical & Computational Biology
gene expression
microRNA
Fokker-Planck equations
inverse gamma distributions
BRUNN-MINKOWSKI
INEQUALITIES
MICRORNAS
Fokker-Planck equations
gene expression
inverse gamma distributions
microRNA
Gene Expression
Gene Regulatory Networks
Gene Expression
Gene Regulatory Networks
math.NA
math.NA
cs.NA
math.AP
35Q84, 92C40, 92D20, 35Q92, 65M08
0102 Applied Mathematics
0903 Biomedical Engineering
0904 Chemical Engineering
Bioinformatics
Publication Status
Published
Date Publish Online
2020-09-24