A protocol for the systematic review and meta-analysis of studies in which cannabinoids were tested for antinociceptive effects in animal models of pathological or injury-related persistent pain.
Author(s)
Type
Journal Article
Abstract
Introduction: The International Association for the Study of Pain has established a global task force to comprehensively investigate the use of cannabinoids and cannabis-based medicines for pain management. This systematic review, the first in this field, will assess the preclinical literature that investigates the antinociceptive effects of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators in animal models of tissue damage, inflammation, or neuropathy. Methods: A systematic electronic search of 3 online databases will identify relevant studies in which cannabinoids, cannabis-based medicines, and endocannabinoid system modulators have been tested in animal models of injury-related or pathological persistent pain. Data will be extracted for pain-associated behavioural outcomes, study design, and the reporting of measures to avoid bias. Standardised mean difference meta-analysis will be used to provide summary estimates of efficacy, with the effects of study quality and study design explored using stratified meta-analysis. Perspective: The evaluation of the preclinical evidence will quantify the antinociceptive effects of cannabinoids on pain behaviour in animal models of pathological pain in an effort to quantify the presence and prevalence of analgesic efficacy. It will also provide an understanding of the strengths and weaknesses of the preclinical field and inform an agenda for future research.
Date Issued
2019-07
Date Acceptance
2019-05-25
Citation
PAIN Reports, 2019, 4 (4), pp.1-6
ISSN
2471-2531
Publisher
Lippincott, Williams & Wilkins
Start Page
1
End Page
6
Journal / Book Title
PAIN Reports
Volume
4
Issue
4
Copyright Statement
© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf
of The International Association for the Study of Pain. This is an open access article
distributed under the Creative Commons Attribution-NoDerivatives License 4.0 (CC
BY-ND) which allows for redistribution, commercial and non-commercial, as long as
it is passed along unchanged and in whole, with credit to the author.
of The International Association for the Study of Pain. This is an open access article
distributed under the Creative Commons Attribution-NoDerivatives License 4.0 (CC
BY-ND) which allows for redistribution, commercial and non-commercial, as long as
it is passed along unchanged and in whole, with credit to the author.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31579857
PII: PAINREPORTS-D-19-0034
Subjects
Animal models
Cannabinoids
Cannabis
Endocannabinoid system modulators
Pain
Systematic review
Publication Status
Published online
Coverage Spatial
United States
Date Publish Online
2019-07