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A review of macrophage microRNAs' role in human asthma
File(s)
Author(s)
Feketea, Gavriela
Bocsan, Corina
Popescu, Cristian
Gaman, Mihaela
Stanciu, Luminita A
Type
Journal Article
Abstract
There is an imbalance in asthma between classically activated macrophages (M1 cells) and alternatively activated macrophages (M2 cells) in favor of the latter. MicroRNAs (miRNAs) play a critical role in regulating macrophage proliferation and differentiation and control the balance of M1 and M2 macrophage polarization, thereby controlling immune responses. Here we review the current published data concerning miRNAs with known correlation to a specific human macrophage phenotype and polarization, and their association with adult asthma. MiRNA-targeted therapy is still in the initial stages, but clinical trials are under recruitment or currently running for some miRNAs in other diseases. Regulating miRNA expression via their upregulation or downregulation could show potential as a novel therapy for improving treatment efficacy in asthma.
Date Issued
2019-05-08
Date Acceptance
2019-05-07
Citation
Cells, 2019, 8 (5), pp.1-21
URI
URL
DOI
ISSN
2073-4409
Publisher
MDPI AG
Start Page
1
End Page
21
Journal / Book Title
Cells
Volume
8
Issue
5
Copyright Statement
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000470994400040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
asthma
molecular asthma
macrophages
microRNA
KAPPA-B PATHWAY
ALLERGIC INFLAMMATION
DENDRITIC CELL
MOUSE MODEL
EXPRESSION
POLARIZATION
ACTIVATION
OVEREXPRESSION
PROLIFERATION
INDUCTION
Publication Status
Published
Article Number
ARTN 420
Date Publish Online
2019-05-08