Sensing infection and tissue damage
File(s)
Published version
Author(s)
Reis e Sousa, C
Type
Journal Article
Abstract
Innate and adaptive immunity work concertedly in vertebrates to restore homoeostasis following pathogen invasion or other insults. Like all homoeostatic circuits, immunity relies on an integrated system of sensors, transducers and effectors that can be analysed in cellular or molecular terms. At the cellular level, T and B lymphocytes act as an effector arm of immunity that is mobilised in response to signals transduced by innate immune cells that detect a given insult. These innate cells are spread around the body and include dendritic cells (DCs), the chief immune sensors of pathogen invasion and tumour growth. At the molecular level, DCs possess receptors that directly sense pathogen presence and tissue damage and that signal via transduction pathways to control antigen presentation or regulate a plethora of genes encoding effector proteins that regulate immunity. Notably, molecular circuits for pathogen detection are not confined to DCs or even to immune cells. All cells express sensors and transducers that monitor invasion by viruses and bacteria and elicit suitable effector barriers to pathogen propagation. Here, I discuss work from my laboratory that has contributed to our understanding of these issues over the years.
Date Issued
2017-01-24
Date Acceptance
2017-01-01
Citation
EMBO Molecular Medicine, 2017, 9 (3), pp.285-288
ISSN
1757-4676
Publisher
Wiley
Start Page
285
End Page
288
Journal / Book Title
EMBO Molecular Medicine
Volume
9
Issue
3
Copyright Statement
© 2017 The Author. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000397296000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
SINGLE-STRANDED RNA
ANTIVIRAL RESPONSES
CELLS
RECOGNITION
IMMUNITY
INDUCTION
RECEPTOR
REVEALS
PATHWAY
DNGR-1
Publication Status
Published