Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection
File(s)
Published version
OA Location
Author(s)
Rosadas, Carolina
Tosswill, Jennifer H
Tedder, Richard
Taylor, Graham P
Type
Journal Article
Abstract
Mother-to-child-transmission (MTCT) of human T-cell lymphotropic virus type-1(HTLV-1) contributes disproportionately to the burden of HTLV-1 associated diseases. All preventive measures to avoid MTCT rely on the identification of infected mothers. However, the impact of pregnancy on HTLV-1 diagnosis has not been clearly assessed. Paired samples from 21 HTLV-1 infected women taken during pregnancy and while not pregnant were analysed by CMIA and PCR. The signal-to-cut-off values (S/CO) were higher during pregnancy than in the paired non-pregnant samples. HTLV-1 proviral load did not alter significantly by pregnant state. S/CO positively correlated with HTLV proviral load. Pregnancy does not impair the diagnosis of HTLV-1/2, by either immunological (CMIA) or molecular (qPCR/nPCR) tests.
Date Issued
2019-09-12
Date Acceptance
2019-08-29
Citation
PLoS Neglected Tropical Diseases, 2019, 13 (9)
ISSN
1935-2727
Publisher
Public Library of Science
Journal / Book Title
PLoS Neglected Tropical Diseases
Volume
13
Issue
9
Copyright Statement
© 2019 Rosadas et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
access article distributed under the terms of the
Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31513603
PII: PNTD-D-19-00684
Subjects
06 Biological Sciences
11 Medical and Health Sciences
Tropical Medicine
Publication Status
Published
Coverage Spatial
United States
Article Number
e0007736
Date Publish Online
2019-09-12