Pump function curve shape for a model lymphatic vessel
File(s)Lym.pmpfninfluences.v14.doc (294.5 KB)
Accepted version
Author(s)
Bertram, CD
Macaskill, C
Moore Jr, JE
Type
Journal Article
Abstract
The transport capacity of a contractile segment of lymphatic vessel is defined by its pump function curve relating mean flow-rate and adverse pressure difference. Numerous system characteristics affect curve shape and the magnitude of the generated flow-rates and pressures. Some cannot be varied experimentally, but their separate and interacting effects can be systematically revealed numerically. This paper explores variations in the rate of change of active tension and the form of the relation between active tension and muscle length, factors not known from experiment to functional precision. Whether the pump function curve bends toward or away from the origin depends partly on the curvature of the passive pressure-diameter relation near zero transmural pressure, but rather more on the form of the relation between active tension and muscle length. A pump function curve bending away from the origin defines a well-performing pump by maximum steady output power. This behaviour is favoured by a length/active-tension relationship which sustains tension at smaller lengths. Such a relationship also favours high peak mechanical efficiency, defined as output power divided by the input power obtained from the lymphangion diameter changes and active-tension time-course. The results highlight the need to pin down experimentally the form of the active tension/length relationship.
Date Issued
2016-05-13
Date Acceptance
2016-04-08
Citation
Medical Engineering & Physics, 2016, 38 (7), pp.656-663
ISSN
1873-4030
Publisher
Elsevier
Start Page
656
End Page
663
Journal / Book Title
Medical Engineering & Physics
Volume
38
Issue
7
Copyright Statement
© 2016 IPEM. Published by Elsevier Ltd. All rights reserved. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
The Royal Society
Royal Academy Of Engineering
National Institutes of Health
National Institutes of Health
Grant Number
WM120065
N/A
TEES No. C09-00903
1U01HL123420-01
Subjects
Biomedical Engineering
02 Physical Sciences
09 Engineering
11 Medical And Health Sciences
Publication Status
Published