Dedifferentiation of neurons precedes tumor gormation in lola mutants
File(s)
Published version
Author(s)
Southall, Tony D
Davidson, Catherine M
Miller, Claire
Carr, Adrian
Brand, Andrea H
Type
Journal Article
Abstract
The ability to reprogram differentiated cells into a pluripotent state has revealed that the differentiated state is plastic and reversible. It is evident, therefore, that mechanisms must be in place to maintain cells in a differentiated state. Transcription factors that specify neuronal characteristics have been well studied, but less is known about the mechanisms that prevent neurons from dedifferentiating to a multipotent, stem cell-like state. Here, we identify Lola as a transcription factor that is required to maintain neurons in a differentiated state. We show that Lola represses neural stem cell genes and cell-cycle genes in postmitotic neurons. In lola mutants, neurons dedifferentiate, turn on neural stem cell genes, and begin to divide, forming tumors. Thus, neurons rather than stem cells or intermediate progenitors are the tumor-initiating cells in lola mutants.
Date Issued
2014-03-31
Date Acceptance
2014-01-30
Citation
Developmental Cell, 2014, 28 (6), pp.685-696
ISSN
1534-5807
Publisher
Elsevier
Start Page
685
End Page
696
Journal / Book Title
Developmental Cell
Volume
28
Issue
6
Copyright Statement
© 2014 The Authors. Published by Elsevier Inc. User rights governed by an Open Access license.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333765900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Developmental Biology
NEURAL STEM-CELLS
NEUROBLAST SELF-RENEWAL
HOMEOBOX PROTEIN PROX1
CENTRAL-NERVOUS-SYSTEM
TRANSCRIPTION FACTOR
DROSOPHILA-MELANOGASTER
EMBRYONIC-DEVELOPMENT
ASYMMETRIC DIVISION
SPINDLE ORIENTATION
TRANSGENIC RNAI
Publication Status
Published
Date Publish Online
2014-03-13