The developing human connectome project: A minimal processing pipeline for neonatal cortical surface reconstruction.
File(s)125526.full.pdf (22.35 MB)
Accepted version
OA Location
Author(s)
Type
Journal Article
Abstract
The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this connectome in detail may provide insights into normal as well as abnormal patterns of brain development. Following established best practices adopted by the WU-MINN Human Connectome Project (HCP), and pioneered by FreeSurfer, the project utilises cortical surface-based processing pipelines. In this paper, we propose a fully automated processing pipeline for the structural Magnetic Resonance Imaging (MRI) of the developing neonatal brain. This proposed pipeline consists of a refined framework for cortical and sub-cortical volume segmentation, cortical surface extraction, and cortical surface inflation, which has been specifically designed to address considerable differences between adult and neonatal brains, as imaged using MRI. Using the proposed pipeline our results demonstrate that images collected from 465 subjects ranging from 28 to 45 weeks post-menstrual age (PMA) can be processed fully automatically; generating cortical surface models that are topologically correct, and correspond well with manual evaluations of tissue boundaries in 85% of cases. Results improve on state-of-the-art neonatal tissue segmentation models and significant errors were found in only 2% of cases, where these corresponded to subjects with high motion. Downstream, these surfaces will enhance comparisons of functional and diffusion MRI datasets, supporting the modelling of emerging patterns of brain connectivity.
Date Issued
2018-01-30
Date Acceptance
2018-01-21
Citation
NeuroImage, 2018, 173, pp.88-112
ISSN
1053-8119
Publisher
Elsevier
Start Page
88
End Page
112
Journal / Book Title
NeuroImage
Volume
173
Copyright Statement
© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Commission of the European Communities
Identifier
PII: S1053-8119(18)30054-5
Grant Number
319456
Subjects
Cortical surface reconstruction
Developing human connectome project
Neonatal MRI
Pipeline
Segmentation
dHCP
Publication Status
Published
Date Publish Online
2018-01-31