Prevalence and burden of chronic bronchitis symptoms: results from the BOLD study
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study.
Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years.
Data from 24 855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10.8% in Lexington (KY, USA), to 0% in Ile-Ife (Nigeria) and Blantyre (Malawi). Older age, less education, current smoking, occupational exposure to fumes, self-reported diagnosis of asthma or lung cancer and family history of chronic lung disease were all associated with increased risk of chronic bronchitis. Chronic bronchitis symptoms were associated with worse lung function, more dyspnoea, increased risk of respiratory exacerbations and reduced quality of life, independent of the presence of other lung diseases.
The prevalence of chronic bronchitis symptoms varied widely across the studied sites. Chronic bronchitis symptoms were associated with significant burden both in individuals with chronic airflow obstruction and those with normal lung function.
Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years.
Data from 24 855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10.8% in Lexington (KY, USA), to 0% in Ile-Ife (Nigeria) and Blantyre (Malawi). Older age, less education, current smoking, occupational exposure to fumes, self-reported diagnosis of asthma or lung cancer and family history of chronic lung disease were all associated with increased risk of chronic bronchitis. Chronic bronchitis symptoms were associated with worse lung function, more dyspnoea, increased risk of respiratory exacerbations and reduced quality of life, independent of the presence of other lung diseases.
The prevalence of chronic bronchitis symptoms varied widely across the studied sites. Chronic bronchitis symptoms were associated with significant burden both in individuals with chronic airflow obstruction and those with normal lung function.
Date Issued
2017-11-22
Date Acceptance
2017-08-11
Citation
European Respiratory Journal, 2017, 50 (5)
ISSN
0903-1936
Publisher
European Respiratory Society
Journal / Book Title
European Respiratory Journal
Volume
50
Issue
5
Copyright Statement
Copyright ©ERS 2017
This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.
This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.
License URL
Sponsor
Kaiser Foundation Hospitals,Center for Health Research
Sociedade Portuguesa de Pneumologia
Tartu University Hospital
Wellcome Trust
Wellcome Trust
Ciro Horn
Grant Number
DHTBX_P19127
DHTBX_P18236
DHTBX_P19125
085790/Z/08/Z
089405/Z/09/Z
DHTBX_P19121
Subjects
BOLD collaborators
BOLD study collaborators
11 Medical And Health Sciences
Respiratory System
Publication Status
Published
Article Number
1700621