Fiber size-selective stimulation using action potential filtering for a peripheral nerve interface: A simulation study
File(s)EMBC15_2290_FI.pdf (951.52 KB)
Accepted version
Author(s)
Rapeaux, A
Nikolic, K
Williams, I
Eftekhar, A
Constandinou, TG
Type
Conference Paper
Abstract
Functional electrical stimulation is a powerful
tool for restoration of function after nerve injury. However
selectivity of stimulation remains an issue. This paper presents
an alternative stimulation technique to obtain fiber size-selective
stimulation of nerves using FDA-approved electrode implants.
The technique was simulated for the ventral roots of
Xenopus Laevis, motivated by an application in bladder control. The
technique relies on applying a high frequency alternating
current to filter out action potentials in larger fibers, resulting
in selective stimulation of the smaller fibers. Results predict that
the technique can distinguish fibers with only a 2 µm difference
in diameter (for nerves not exceeding 2 mm in diameter). The
study investigates the behaviour of electrically blocked nerves
in detail. Model imperfections and simplifications yielded some
artefacts in the results, as well as unexpected nerve behaviour
which is tentatively explained.
tool for restoration of function after nerve injury. However
selectivity of stimulation remains an issue. This paper presents
an alternative stimulation technique to obtain fiber size-selective
stimulation of nerves using FDA-approved electrode implants.
The technique was simulated for the ventral roots of
Xenopus Laevis, motivated by an application in bladder control. The
technique relies on applying a high frequency alternating
current to filter out action potentials in larger fibers, resulting
in selective stimulation of the smaller fibers. Results predict that
the technique can distinguish fibers with only a 2 µm difference
in diameter (for nerves not exceeding 2 mm in diameter). The
study investigates the behaviour of electrically blocked nerves
in detail. Model imperfections and simplifications yielded some
artefacts in the results, as well as unexpected nerve behaviour
which is tentatively explained.
Date Issued
2015-08
Date Acceptance
2015-06-30
Citation
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015, pp.3411-3414
Start Page
3411
End Page
3414
Journal / Book Title
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Copyright Statement
© 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Source
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Publication Status
Published
Start Date
2015-08-25
Finish Date
2015-08-29
Coverage Spatial
Milan, Italy