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Population-based data at ages 31 and 46 show decreased HRQoL and life satisfaction in women with PCOS symptoms.
File(s)
Author(s)
Karjula, Salla
Morin-Papunen, Laure
Franks, Stephen
Auvinen, Juha
Järvelin, Marjo-Riitta
Type
Journal Article
Abstract
CONTEXT: Polycystic ovary syndrome (PCOS) is associated with decreased health-related quality of life (HRQoL), but longitudinal data beyond the reproductive years are lacking, and the impact of isolated PCOS symptoms is unclear. OBJECTIVE: To study generic HRQoL using 15D, life satisfaction, and self-reported health status in women with PCOS symptoms at ages 31 and 46yr. DESIGN: A longitudinal assessment using the Northern Finland Birth Cohort 1966. SETTING: General community. PARTICIPANTS: The 15D data were available for women reporting isolated oligomenorrhea (OA;at age 31yr:214 and 46yr: 211), isolated hirsutism (H; 31yr:211 and 46yr:216), OA+H (PCOS; 31yr:74 and 46yr:75), or no PCOS symptoms (controls; 31yr:1382 and 46yr:1412). Data for life satisfaction and current health status were available for OA (31yr:329 and 46yr:247), H (31yr:323 and 46yr:238), PCOS (31yr:125 and 46yr:86), control (31yr:2182 and 46yr:1613) groups. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): 15D HRQoL, questionnaires on life satisfaction, and self-reported health status. RESULTS: HRQoL was lower at ages 31 and 46 in women with PCOS or H compared with the controls. PCOS was an independent risk factor for low HRQoL, and the decrease in HRQoL in PCOS was comparable to that of women with other chronic conditions, like asthma, migraine, rheumatoid arthritis, and depression. The risk for low HRQoL in PCOS remained significant after adjusting for BMI, hyperandrogenism, and socioeconomic status. Mental distress was the strongest contributing factor to HRQoL. PCOS was also associated with a risk for low life satisfaction and a 4-fold risk for reporting a poor health status. CONCLUSIONS: Women with PCOS present with low HRQoL, decreased life satisfaction, and a poorer self-reported health status up to their late reproductive years. Assessments and interventions aiming to improve HRQoL in PCOS should be targeted beyond fertile age.
Date Issued
2020-01-23
Date Acceptance
2020-01-01
Citation
Journal of Clinical Endocrinology and Metabolism, 2020, 105 (6), pp.1-13
URI
URL
DOI
ISSN
0021-972X
Publisher
Oxford University Press (OUP)
Start Page
1
End Page
13
Journal / Book Title
Journal of Clinical Endocrinology and Metabolism
Volume
105
Issue
6
Copyright Statement
© Endocrine Society 2020. All rights reserved. For permissions, please e-mail:
journals.permissions@oup.com. jc.2019-00946. See endocrine.org/publications for Accepted
Manuscript disclaimer and additional information. This is a pre-copy-editing, author-produced version of an article accepted for publication in The Journal of Clinical Endocrinology & Metabolism following peer review. The definitive publisher-authenticated version Salla Karjula, Laure Morin-Papunen, Stephen Franks, Juha Auvinen, Marjo-Riitta Järvelin, Juha S Tapanainen, Jari Jokelainen, Jouko Miettunen, Terhi T Piltonen, Population-based data at ages 31 and 46 show decreased HRQoL and life satisfaction in women with PCOS symptoms, The Journal of Clinical Endocrinology & Metabolism, is available online at: https://doi.org/10.1210/clinem/dgz256
Sponsor
MRC
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31970392
PII: 5709653
Grant Number
G0802782
Subjects
FAI
PCOS
QoL
aging
hirsutism
testosterone
Publication Status
Published online
Coverage Spatial
United States
Date Publish Online
2020-01-23