An analytical pipeline for quantitative characterization of dietary intake: application to assess grape intake.
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Lack of accurate dietary assessment in free-living populations requires discovery of new biomarkers reflecting food intake qualitatively and quantitatively to objectively evaluate effects of diet on health. We provide a proof-of-principle for an analytical pipeline to identify quantitative dietary biomarkers. Tartaric acid was identified as dose-responsive urinary biomarker of grape intake and subsequently quantified in volunteers who followed a series of 4-day dietary interventions incorporating 0g/day, 50g/day, 100g/day and 150g/day of grapes in standardized diets from a randomized controlled clinical trial. The most accurate quantitative prediction of grape intake was obtained in 24h urine samples which have the strongest linear relationship between grape intake and tartaric acid excretion (r2=0.90). This new methodological pipeline for estimating nutritional intake based on coupling dietary intake information and quantified nutritional biomarkers was developed and validated in a controlled dietary intervention study, showing that this approach can improve the accuracy of estimating nutritional intakes.
Date Issued
2016-02-24
Date Acceptance
2016-02-24
Citation
Journal of Agricultural and Food Chemistry, 2016, 64 (11), pp.2423-2431
ISSN
1520-5118
Publisher
American Chemical Society
Start Page
2423
End Page
2431
Journal / Book Title
Journal of Agricultural and Food Chemistry
Volume
64
Issue
11
Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.jafc.5b05878
Sponsor
National Institute for Health Research
Medical Research Council (MRC)
National Institute for Health Research
Royal Society Of Chemistry
Grant Number
PDF-2012-05-456
10731
NF-SI-0513-10029
TWAF15/02
Subjects
accurate dietary assessment
metabolic profiling
nutritional intake
quantified dietary biomarkers
tartaric acid
Food Science
03 Chemical Sciences
07 Agricultural And Veterinary Sciences
09 Engineering
Publication Status
Published