The role of CD4+T follicular helper cells in HIV infection: from the germinal center to the periphery
File(s)
Published version
Author(s)
Thornhill, JP
Fidler, S
Klenerman, P
Frater, J
Phetsouphanh, C
Type
Journal Article
Abstract
T follicular helper cells (TFh) are key components of the adaptive immune system; they are primarily found in germinal centers (GCs) where their interaction with B cells supports humoral immune responses and efficient antibody production. They are defined by the expression of CXC receptor 5, program death-1, ICOS, and secretion of IL-21. Their differentiation is regulated by B-cell lymphoma 6. The relationship and function of circulating TFh to bona fide TFh resident in the GC is much debated. HIV infection impacts the TFh response with evidence of aberrant TFh function observed in acute and chronic infection. Effective TFh responses are associated with the development of broadly neutralizing antibody responses to HIV and may be important for viral control. In addition, TFh are preferentially infected and act as a key reservoir for latent HIV infection. This review explores recent developments in our understanding of TFh differentiation, regulation, function, and the relationship between cTFh and those in GCs, and the complex interaction between TFh and HIV infection.
Date Issued
2017-01-30
Date Acceptance
2017-01-11
Citation
Frontiers in Immunology, 2017, 8
ISSN
1664-3224
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Immunology
Volume
8
Copyright Statement
© 2017 Thornhill, Fidler, Klenerman, Frater and Phetsouphanh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
British HIV Association (BHIVA)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000392746800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
MR/L00528X/1
MR/N001265/1
N/A
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
HIV
Tfh cells
reservoir
T cells
viral immunity
CD4(+) T-CELLS
CXC CHEMOKINE RECEPTOR-5
CHRONIC VIRAL-INFECTION
ANTIBODY-RESPONSES
B-CELLS
RHESUS MACAQUES
SIV INFECTION
TFH CELLS
EXPRESSION
CXCR5(+)
Publication Status
Published
Article Number
ARTN 46