Considerations for obstetric management of births 22–25 weeks’ gestation
File(s)
Author(s)
Type
Journal Article
Abstract
Preterm birth between 22 and 25 5/7 weeks complicates <1% of live births within the United States though contributes more than 20% of infant mortality within the first year of life. Ante- and intrapartum interventions such as antenatal corticosteroids, magnesium sulfate, and tocolytic and antibiotic therapies have been shown effective in optimizing postnatal prognosis in births at 24 weeks and beyond. Interventions, mode of delivery, and resuscitation plans should ideally be discussed with the perinatology, neonatology, and nursing teams with the family using shared decision making. Observational data have alluded to similar postnatal benefits in births at 22–23 weeks; however, these data are limited by small sample sizes, inconsistencies in outcome reporting, and variations in management strategies. Future studies to evaluate the utility of these interventions among births at 22–23 weeks are warranted.
Date Issued
2025-04-11
Date Acceptance
2025-03-26
Citation
Journal of Perinatology, 2025
ISSN
0743-8346
Publisher
Springer Nature [academic journals on nature.com]
Journal / Book Title
Journal of Perinatology
Copyright Statement
© 2025, The Author(s), under exclusive licence to Springer Nature America, Inc. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Publication Status
Published online
Date Publish Online
2025-04-11