Grading the severity of anaphylaxis
File(s)Grading severity of anaphylaxis Curr Opin.docx (1.18 MB)
Accepted version
Author(s)
Turner, Paul
Stafford, Aisling
Type
Journal Article
Abstract
Purpose of review
Despite no global consensus on a definition of anaphylaxis, there is increasing recognition that just as allergic reactions lie on a spectrum of severity, the same is for anaphylaxis. A variety of severity scores exist in the literature. We review the approaches taken to develop these scores, and their relative advantages and disadvantages.
Recent findings
There have been four recent comparisons of published severity scores. All have highlighted the heterogeneity between scoring systems, and the lack of transferability from one approach to another. Notably, only one score has been developed using a data-driven approach, and none has undergone formal and comprehensive validation.
Summary
It is unclear whether a single severity score is achievable, or indeed desirable. If the aim is to guide management of acute reactions, then assignment of severity is not only unnecessary but might delay treatment and cause harm. Severity scores are needed in the research setting, but require an approach which can discriminate between reactions of similar but nonidentical severity (particularly, nonanaphylaxis reactions). Any approach should be fit for purpose, informed by patient and clinician experience, and ideally be data-driven to minimize subjective bias and facilitate objective validation.
Despite no global consensus on a definition of anaphylaxis, there is increasing recognition that just as allergic reactions lie on a spectrum of severity, the same is for anaphylaxis. A variety of severity scores exist in the literature. We review the approaches taken to develop these scores, and their relative advantages and disadvantages.
Recent findings
There have been four recent comparisons of published severity scores. All have highlighted the heterogeneity between scoring systems, and the lack of transferability from one approach to another. Notably, only one score has been developed using a data-driven approach, and none has undergone formal and comprehensive validation.
Summary
It is unclear whether a single severity score is achievable, or indeed desirable. If the aim is to guide management of acute reactions, then assignment of severity is not only unnecessary but might delay treatment and cause harm. Severity scores are needed in the research setting, but require an approach which can discriminate between reactions of similar but nonidentical severity (particularly, nonanaphylaxis reactions). Any approach should be fit for purpose, informed by patient and clinician experience, and ideally be data-driven to minimize subjective bias and facilitate objective validation.
Date Issued
2023-06
Date Acceptance
2023-03-01
Citation
Current Opinion in Allergy and Clinical Immunology, 2023, 23 (3), pp.218-225
ISSN
1473-6322
Publisher
Lippincott, Williams & Wilkins
Start Page
218
End Page
225
Journal / Book Title
Current Opinion in Allergy and Clinical Immunology
Volume
23
Issue
3
Copyright Statement
Copyright © 2023 Lippincott Williams & Wilkins, Inc. This is a non-final version of an article published in final form in Stafford, Aisling; Turner, Paul J. Grading the severity of anaphylaxis. Current Opinion in Allergy and Clinical Immunology: 10.1097/ACI.0000000000000901, March 15, 2023.
Identifier
https://journals.lww.com/co-allergy/Fulltext/9900/Grading_the_severity_of_anaphylaxis.49.aspx
Publication Status
Published
Date Publish Online
2023-03-15