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Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: a systematic review and meta-analysis.
File(s)
ciy401.pdf (807.35 KB)
Published version
Author(s)
Parks, Tom
Wilson, Clare
Curtis, Nigel
Norrby-Teglund, Anna
Sriskandan, S
Type
Journal Article
Abstract
We evaluated the effect of adjunctive intravenous immunoglobulin (IVIG) on mortality in clindamycin-treated streptococcal toxic shock syndrome patients using a meta-analysis. In association with IVIG, mortality fell from 33.7% to 15.7% (risk ratio 0.46, 95% confidence intervals 0.26-0.83, p=0.010) with remarkable consistency across the single randomised and four non-randomised studies.
Date Issued
2018-11
Date Acceptance
2018-05-15
Citation
Clinical Infectious Diseases, 2018, 67 (9), pp.1434-1436
URI
URL
DOI
ISSN
1058-4838
Publisher
Oxford University Press (OUP)
Start Page
1434
End Page
1436
Journal / Book Title
Clinical Infectious Diseases
Volume
67
Issue
9
Copyright Statement
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor
National Institute for Health Research
National Institute for Health Research
Identifier
https://academic.oup.com/cid/article/67/9/1434/4996609
Grant Number
HPRU-2012-10047
HPRU-2012-10047
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
Group A streptococcus
Streptococcus pyogenes
intravenous immunoglobulin
streptococcal toxic shock syndrome
necrotising fasciitis
THERAPY
INFECTIONS
DISEASE
06 Biological Sciences
11 Medical and Health Sciences
Microbiology
Publication Status
Published
Date Publish Online
2018-05-18