COVID-2019: Molecular and cellular response
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
In late December 2019 a viral pneumonia with an unknown agent was reported in Wuhan, China. A novel coronavirus was identified as the causative agent. Because of the human-to-human transmission and rapid spread; coronavirus disease 2019 (COVID-19) has rapidly increased to an epidemic scale and poses a severe threat to human health; it has been declared a public health emergency of international concern (PHEIC) by the World Health Organization (WHO). This review aims to summarize the recent research progress of COVID-2019 molecular features and immunopathogenesis to provide a reference for further research in prevention and treatment of SARS coronavirus2 ( SARS-CoV-2) infection based on the knowledge from researches on SARS-CoV and Middle East respiratory syndrome-related coronavirus(MERS-CoV.)
Date Issued
2021-02
Date Acceptance
2021-01-08
Citation
Frontiers in Cellular and Infection Microbiology, 2021, 11, pp.1-16
ISSN
2235-2988
Publisher
Frontiers Media
Start Page
1
End Page
16
Journal / Book Title
Frontiers in Cellular and Infection Microbiology
Volume
11
Copyright Statement
© 2021 Alipoor, Mortaz, Jamaati, Tabarsi, Bayram, Varahram and Adcock. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Sponsor
Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Medical Research Council (MRC)
Identifier
https://www.frontiersin.org/articles/10.3389/fcimb.2021.563085/full
Grant Number
208340/Z/17/Z
EP/T003189/1
MR/T010371/1
Subjects
ACE2
COVID-19
IL-6
IL-8
cytokines
Humans
Cytokines
Virus Internalization
Immunity, Innate
Adaptive Immunity
Spike Glycoprotein, Coronavirus
COVID-19
Angiotensin-Converting Enzyme 2
SARS-CoV-2
0601 Biochemistry and Cell Biology
0605 Microbiology
Publication Status
Published
Article Number
563085
Date Publish Online
2021-02-11