Non-equilibrium correlations in minimal dynamical models of polymer copying
File(s)
Accepted version
Author(s)
Poulton, Jenny
Wolde, Pieter Rein ten
Ouldridge, Thomas E
Type
Journal Article
Abstract
Living systems produce "persistent" copies of information-carrying polymers, in which template and copy sequences remain correlated after physically decoupling. We identify a general measure of the thermodynamic efficiency with which these non-equilibrium states are created, and analyze the accuracy and efficiency of a family of dynamical models that produce persistent copies. For the weakest chemical driving, when polymer growth occurs in equilibrium, both the copy accuracy and, more surprisingly, the efficiency vanish. At higher driving strengths, accuracy and efficiency both increase, with efficiency showing one or more peaks at moderate driving. Correlations generated within the copy sequence, as well as between template and copy, store additional free energy in the copied polymer and limit the single-site accuracy for a given chemical work input. Our results provide insight in the design of natural self-replicating systems and can aid the design of synthetic replicators.
Date Issued
2019-02-05
Date Acceptance
2018-12-12
Citation
Proceedings of the National Academy of Sciences, 2019, 116 (6), pp.1946-1951
ISSN
0027-8424
Publisher
National Academy of Sciences
Start Page
1946
End Page
1951
Journal / Book Title
Proceedings of the National Academy of Sciences
Volume
116
Issue
6
Copyright Statement
© 2019 The Author(s). Published under the PNAS license (https://www.pnas.org/page/authors/licenses)
Sponsor
The Royal Society
Identifier
http://arxiv.org/abs/1805.08502v1
Grant Number
UF150067
Subjects
cond-mat.stat-mech
cond-mat.stat-mech
Publication Status
Published
Date Publish Online
2019-02-05