Two Stage Sub-Wavelength Motion Correction in Human Microvasculature for CEUS Imaging
File(s)
Accepted version
Author(s)
Type
Conference Paper
Abstract
The structure of microvasculature cannot be resolved using clinical B-mode or contrast-enhanced ultrasound (CEUS) imaging due to the fundamental diffraction limit at clinical ultrasound frequencies. It is possible to overcome this resolution limitation by localizing individual microbubbles through multiple frames and forming a super-resolved image. However, ultrasound super-resolution creates its unique problems since the structures to be imaged are on the order of 10s of μm. Tissue movement much larger than 10 μm is common in clinical imaging, which can significantly reduce the accuracy of super-resolution images created from microbubble locations gathered through hundreds of frames. This study investigated an existing motion estimation algorithm from magnetic resonance imaging for ultrasound super-resolution imaging. Its correction accuracy is evaluated using simulations with increasing complexity of motion. Feasibility of the method for ultrasound super-resolution in vivo is demonstrated on clinical ultrasound images. For a chosen microvessel, the super-resolution image without motion correction achieved a sub-wavelength resolution; however after the application of proposed two-stage motion correction method the size of the vessel was reduced to half.
Date Issued
2017-11-02
Date Acceptance
2017-09-01
Citation
2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 2017
ISSN
1948-5719
Publisher
IEEE
Journal / Book Title
2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)
Copyright Statement
© 2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416948402036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
EP/N015487/1
Source
IEEE International Ultrasonics Symposium (IUS)
Subjects
LOCALIZATION MICROSCOPY
ULTRASOUND
MICROBUBBLES
RESOLUTION
IMAGES
Publication Status
Published
Start Date
2017-09-06
Finish Date
2017-09-09
Coverage Spatial
Washington, DC