Dearomatising Claisen rearrangements
File(s)
Author(s)
Mullins, Toby
Type
Thesis
Abstract
This thesis is divided into four chapters.
Chapter one is a review of dearomatising [3,3]-sigmatropic rearrangements and is split by sub-classification
of Claisen rearrangements.
Chapter two introduces the decarboxylative Claisen rearrangement (dCr) and details investigations of the
application of this reaction to compounds containing furan rings.
Chapter three focuses on the natural product hinckdentine A. It begins with a brief review of previous
studies towards the natural product, before discussing attempts to synthesise this compound by a
decarboxylative Claisen rearrangement. Chapter four provides experimental procedures and characterisation data.
Chapter one is a review of dearomatising [3,3]-sigmatropic rearrangements and is split by sub-classification
of Claisen rearrangements.
Chapter two introduces the decarboxylative Claisen rearrangement (dCr) and details investigations of the
application of this reaction to compounds containing furan rings.
Chapter three focuses on the natural product hinckdentine A. It begins with a brief review of previous
studies towards the natural product, before discussing attempts to synthesise this compound by a
decarboxylative Claisen rearrangement. Chapter four provides experimental procedures and characterisation data.
Version
Open Access
Date Issued
2015-08
Date Awarded
2016-01
Copyright Statement
Attribution NoDerivatives 4.0 International Licence (CC BY-ND)
Advisor
Craig, Donald
Publisher Department
Chemistry
Publisher Institution
Imperial College London
Qualification Level
Doctoral
Qualification Name
Doctor of Philosophy (PhD)