Pulmonary artery denervation for pulmonary arterial hypertension
File(s)
Accepted version
Author(s)
Constantine, Andrew
Dimopoulos, Konstantinos
Type
Journal Article
Abstract
Pulmonary arterial hypertension remains a progressive, life-limiting disease despite optimal medical therapy. Pulmonary artery denervation has arisen as a novel intervention in the treatment of pulmonary arterial hypertension, and other forms of pulmonary hypertension, with the aim of reducing the sympathetic activity of the pulmonary circulation. Pre-clinical studies and initial clinical trials have demonstrated that the technique can be performed safely with some positive effects on clinical, haemodynamic and echocardiographic markers of disease. The scope of the technique in current practice remains limited given the absence of well-designed, large-scale, international randomised controlled clinical trials. This review provides an overview of this exciting new treatment modality, including pathophysiology, technical innovations and recent trial results.
Date Issued
2020-05-01
Date Acceptance
2020-04-16
Citation
Trends in Cardiovascular Medicine, 2020, 31 (4), pp.252-260
ISSN
1050-1738
Publisher
Elsevier
Start Page
252
End Page
260
Journal / Book Title
Trends in Cardiovascular Medicine
Volume
31
Issue
4
Copyright Statement
©2020 Published by Elsevier Inc. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Subjects
Interventional cardiology
Pulmonary arterial hypertension
Pulmonary artery denervation
Pulmonary hypertension
Cardiovascular System & Hematology
1102 Cardiorespiratory Medicine and Haematology
Publication Status
Published
Date Publish Online
2020-05-12