Lipoprotein markers associated with disability from multiple sclerosis
File(s)
Author(s)
Type
Journal Article
Abstract
Altered lipid metabolism is a feature of chronic infammatory disorders. Increased plasma lipids and
lipoproteins have been associated with multiple sclerosis (MS) disease activity. Our objective was to
characterise the specifc lipids and associated plasma lipoproteins increased in MS and to test for an
association with disability. Plasma samples were collected from 27 RRMS patients (median EDSS,
1.5, range 1–7) and 31 healthy controls. Concentrations of lipids within lipoprotein sub-classes were
determined from NMR spectra. Plasma cytokines were measured using the MesoScale Discovery
V-PLEX kit. Associations were tested using multivariate linear regression. Diferences between the
patient and volunteer groups were found for lipids within VLDL and HDL lipoprotein sub-fractions
(p<0.05). Multivariate regression demonstrated a high correlation between lipids within VLDL
sub-classes and the Expanded Disability Status Scale (EDSS) (p<0.05). An optimal model for EDSS
included free cholesterol carried by VLDL-2, gender and age (R2=0.38, p<0.05). Free cholesterol
carried by VLDL-2 was highly correlated with plasma cytokines CCL-17 and IL-7 (R2=0.78, p<0.0001).
These results highlight relationships between disability, infammatory responses and systemic lipid
metabolism in RRMS. Altered lipid metabolism with systemic infammation may contribute to immune
activation.
lipoproteins have been associated with multiple sclerosis (MS) disease activity. Our objective was to
characterise the specifc lipids and associated plasma lipoproteins increased in MS and to test for an
association with disability. Plasma samples were collected from 27 RRMS patients (median EDSS,
1.5, range 1–7) and 31 healthy controls. Concentrations of lipids within lipoprotein sub-classes were
determined from NMR spectra. Plasma cytokines were measured using the MesoScale Discovery
V-PLEX kit. Associations were tested using multivariate linear regression. Diferences between the
patient and volunteer groups were found for lipids within VLDL and HDL lipoprotein sub-fractions
(p<0.05). Multivariate regression demonstrated a high correlation between lipids within VLDL
sub-classes and the Expanded Disability Status Scale (EDSS) (p<0.05). An optimal model for EDSS
included free cholesterol carried by VLDL-2, gender and age (R2=0.38, p<0.05). Free cholesterol
carried by VLDL-2 was highly correlated with plasma cytokines CCL-17 and IL-7 (R2=0.78, p<0.0001).
These results highlight relationships between disability, infammatory responses and systemic lipid
metabolism in RRMS. Altered lipid metabolism with systemic infammation may contribute to immune
activation.
Date Issued
2018-11-16
Date Acceptance
2018-10-18
Citation
Scientific Reports, 2018, 8 (1)
ISSN
2045-2322
Publisher
Nature Publishing Group
Journal / Book Title
Scientific Reports
Volume
8
Issue
1
Copyright Statement
© 2018 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Identifier
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Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
LOW-DENSITY-LIPOPROTEIN
J774 MACROPHAGES
CHOLESTEROL
PROGRESSION
ACCUMULATION
ATORVASTATIN
Publication Status
Published
Article Number
17026
Date Publish Online
2018-11-19