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The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance
File(s)
Author(s)
Satta, Giovanni
Witty, AA
Begum, N
Ortiz Canseco, J
Boa, AN
Type
Journal Article
Abstract
Para-aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is not completely understood yet. The main aim of this project was to identify new potential mechanisms of action and resistance to PAS by performing whole genome sequencing (WGS) on PAS-resistant laboratory mutants. A new variant in the folC gene has been identified as well as some other mutations that require further studies.
Date Issued
2020-08-20
Date Acceptance
2020-06-13
Citation
Antimicrobial Agents and Chemotherapy, 2020, 64 (9)
URI
DOI
ISSN
0066-4804
Publisher
American Society for Microbiology
Journal / Book Title
Antimicrobial Agents and Chemotherapy
Volume
64
Issue
9
Copyright Statement
© 2020 American Society for Microbiology. All Rights Reserved.
Subjects
Microbiology
0605 Microbiology
1108 Medical Microbiology
1115 Pharmacology and Pharmaceutical Sciences
Publication Status
Published
Date Publish Online
2020-06-22