Recent advances in understanding of the pathogenesis of ANCA-associated vasculitis [version 1; referees: 2 approved]
Author(s)
Prendecki, Maria
Pusey, Charles D
Type
Journal Article
Abstract
Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are rare systemic autoimmune diseases characterised by inflammation of small blood vessels. Recent developments have been made in our understanding of the pathogenesis of these diseases, including the pathogenic role of ANCA, neutrophils and monocytes as mediators of injury, dysregulation of the complement system, and the role of T and B cells. Current treatment strategies for AAV are based on broad immunosuppression, which may have significant side effects. Advances in understanding of the pathogenesis of disease have led to the identification of new therapeutic targets which may lead to treatment protocols with less-toxic side effects. The aim of this review is to summarise current information and recent advances in understanding of the pathogenesis of AAV.
Date Issued
2018-07-19
Date Acceptance
2018-07-11
Citation
F1000Research, 2018, 7
ISSN
2046-1402
Publisher
F1000 Research Ltd
Journal / Book Title
F1000Research
Volume
7
Copyright Statement
© 2018 Prendecki M and Pusey CD. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30079228
Subjects
ANCA
Vasculitis
Publication Status
Published
Coverage Spatial
England
Article Number
ARTN 1113