Multicavity [PdnL4](2n+) cages with controlled segregated binding of different guests
File(s)
Published version
Author(s)
Preston, Dan
Lewis, James EM
Crowley, James D
Type
Journal Article
Abstract
Multicavity [Pdn(L)4]2n+ metallosupramolecular cages based on long backboned ligands are an attractive approach to increasing molecular size without loss of the binding specificity conferred by small cavity [Pd2(L)4]4+ assemblies. We herein report the synthesis of two double cavity polypyridyl [Pd3(L)4]6+ cages that bind cisplatin [Pt(NH3)2Cl2] within their internal cavities and interact with triflate (TfO–) on their exohedral faces. We also report the first example of a triple cavity [Pd4(L)4]8+ cage. This cage differs in that the central cavity is phenyl-linked rather than having the pyridyl core as in the peripheral cavities. The difference in cavity character results in selective guest binding of cisplatin in the peripheral cavities, with triflate binding within the central cavity and on the exohedral faces of the peripheral palladium(II) ions. All the cavities could be simultaneously filled by introducing both cisplatin and triflate concurrently, providing the first example of a discrete metallosupramolecular architecture with segregated guest binding in different designed internal cavities. The ligands and cages were characterized by NMR spectroscopy, mass spectrometry, elemental analysis, and, in one case, X-ray crystallography.
Date Issued
2017-02-15
Date Acceptance
2017-01-22
Citation
Journal of the American Chemical Society, 2017, 139 (6), pp.2379-2386
ISSN
1520-5126
Publisher
American Chemical Society
Start Page
2379
End Page
2386
Journal / Book Title
Journal of the American Chemical Society
Volume
139
Issue
6
Copyright Statement
© 2017 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (https://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394482200040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
M2L4 MOLECULAR CAPSULE
SUPRAMOLECULAR CHEMISTRY
COORDINATION CAPSULES
DIRECTED SYNTHESIS
DIELS-ALDER
PT-II
COMPLEXES
ENCAPSULATION
HOST
PD
Publication Status
Published
Date Publish Online
2017-01-23