Novel subtypes of pulmonary emphysema based on spatially-informed lung texture learning: the multi-ethnic study of atherosclerosis (MESA) COPD study.
Author(s)
Type
Journal Article
Abstract
Pulmonary emphysema overlaps considerably with chronic obstructive pulmonary disease (COPD), and is traditionally subcategorized into three subtypes previously identified on autopsy. Unsupervised learning of emphysema subtypes on computed tomography (CT) opens the way to new definitions of emphysema subtypes and eliminates the need of thorough manual labeling. However, CT-based emphysema subtypes have been limited to texture-based patterns without considering spatial location. In this work, we introduce a standardized spatial mapping of the lung for quantitative study of lung texture location and propose a novel framework for combining spatial and texture information to discover spatially-informed lung texture patterns (sLTPs) that represent novel emphysema subtype candidates. Exploiting two cohorts of full-lung CT scans from the MESA COPD (n=317) and EMCAP (n=22) studies, we first show that our spatial mapping enables population-wide study of emphysema spatial location. We then evaluate the characteristics of the sLTPs discovered on MESA COPD, and show that they are reproducible, able to encode standard emphysema subtypes, and associated with physiological symptoms.
Date Issued
2021-12
Date Acceptance
2021-06-24
Citation
IEEE Transactions on Medical Imaging, 2021, 40 (12), pp.3652-3662
ISSN
0278-0062
Publisher
Institute of Electrical and Electronics Engineers
Start Page
3652
End Page
3662
Journal / Book Title
IEEE Transactions on Medical Imaging
Volume
40
Issue
12
Copyright Statement
© 2021 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/
License URL
Sponsor
National Institutes of Health
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/34224349
Grant Number
NIHR
Subjects
Nuclear Medicine & Medical Imaging
08 Information and Computing Sciences
09 Engineering
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2021-07-05