Improvements in prevalence trend fitting and incidence estimation in EPP 2013
File(s)
Author(s)
Type
Journal Article
Abstract
Objective: Describe modifications to the latest version of the Joint United Nations Programme on AIDS (UNAIDS) Estimation and Projection Package component of Spectrum (EPP 2013) to improve prevalence fitting and incidence trend estimation in national epidemics and global estimates of HIV burden.
Methods: Key changes made under the guidance of the UNAIDS Reference Group on Estimates, Modelling and Projections include: availability of a range of incidence calculation models and guidance for selecting a model; a shift to reporting the Bayesian median instead of the maximum likelihood estimate; procedures for comparison and validation against reported HIV and AIDS data; incorporation of national surveys as an integral part of the fitting and calibration procedure, allowing survey trends to inform the fit; improved antenatal clinic calibration procedures in countries without surveys; adjustment of national antiretroviral therapy reports used in the fitting to include only those aged 15–49 years; better estimates of mortality among people who inject drugs; and enhancements to speed fitting.
Results: The revised models in EPP 2013 allow closer fits to observed prevalence trend data and reflect improving understanding of HIV epidemics and associated data.
Methods: Key changes made under the guidance of the UNAIDS Reference Group on Estimates, Modelling and Projections include: availability of a range of incidence calculation models and guidance for selecting a model; a shift to reporting the Bayesian median instead of the maximum likelihood estimate; procedures for comparison and validation against reported HIV and AIDS data; incorporation of national surveys as an integral part of the fitting and calibration procedure, allowing survey trends to inform the fit; improved antenatal clinic calibration procedures in countries without surveys; adjustment of national antiretroviral therapy reports used in the fitting to include only those aged 15–49 years; better estimates of mortality among people who inject drugs; and enhancements to speed fitting.
Results: The revised models in EPP 2013 allow closer fits to observed prevalence trend data and reflect improving understanding of HIV epidemics and associated data.
Date Issued
2014-11-01
Date Acceptance
2014-08-11
Citation
AIDS, 2014, 28 (Suppl 4), pp.S415-S425
ISSN
0269-9370
Publisher
Lippincott Williams & Wilkins
Start Page
S415
End Page
S425
Journal / Book Title
AIDS
Volume
28
Issue
Suppl 4
Copyright Statement
© 2014 Lippincott Williams & Wilkins, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
http://creativecommons.org/licenses/by-nc-nd/4.0
http://creativecommons.org/licenses/by-nc-nd/4.0
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Virology
antiretroviral therapy
mathematical models
models
projections
people who inject drugs
surveillance
PROJECTION PACKAGE
GENERALIZED EPIDEMICS
UNAIDS ESTIMATION
HIV PREVALENCE
INFECTION
MORTALITY
AIDS
Publication Status
Published