Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
Author(s)
Type
Journal Article
Abstract
Background
Traumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo.
Findings
Using [11C]-PK11195 positron emission tomography, a marker of microglial activation, we previously demonstrated thalamic inflammation up to 17 years after traumatic brain injury. Here, we use diffusion MRI to estimate axonal injury and show that thalamic inflammation is correlated with thalamo-cortical tract damage.
Conclusions
These findings support a link between axonal damage and persistent inflammation after brain injury.
Traumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo.
Findings
Using [11C]-PK11195 positron emission tomography, a marker of microglial activation, we previously demonstrated thalamic inflammation up to 17 years after traumatic brain injury. Here, we use diffusion MRI to estimate axonal injury and show that thalamic inflammation is correlated with thalamo-cortical tract damage.
Conclusions
These findings support a link between axonal damage and persistent inflammation after brain injury.
Date Issued
2015-12-01
Date Acceptance
2015-11-25
Citation
Journal of Neuroinflammation, 2015, 12
ISSN
1742-2094
Publisher
BioMed Central
Journal / Book Title
Journal of Neuroinflammation
Volume
12
Copyright Statement
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
License URL
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
Grant Number
MR/K501013/1
MR/L022141/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Neurosciences
Neurosciences & Neurology
Microglia
Translocator protein
Positron emission tomography
Traumatic brain injury
Traumatic axonal injury
PK11195
Thalamus
MICROGLIAL ACTIVATION
AXONAL INJURY
IN-VIVO
ISCHEMIC-STROKE
HEAD-INJURY
NEUROINFLAMMATION
PET
SINGLE
Neurology & Neurosurgery
1103 Clinical Sciences
1109 Neurosciences
1107 Immunology
Publication Status
Published
Article Number
224