The influence of paediatric HIV infection on circulating B cell subsets and CXCR5+ T helper cells
Author(s)
Type
Journal Article
Abstract
Antiretroviral therapy (ART) only partially restores HIV-induced alterations in lymphocyte populations. We assessed B and T cell phenotypes in a cohort of children from a single centre in the United Kingdom with perinatally acquired HIV compared to healthy controls. The majority of HIV infected children (44 of 56) were on fully suppressive combination ART. Children with perinatally acquired HIV had significantly lower memory B and CD4+CD45RO+CXCR5+ [follicular T helper cell (Tfh)-like] T cell percentages. Detectable viraemia was associated with higher CD21– (activated and exhausted/tissue-like memory) B cells. A greater proportion of life spent on suppressive ART was associated with higher memory B cell percentages. These results suggest that early and sustained suppressive ART may preserve B and T cell phenotypes in perinatally acquired HIV and limit deficits in humoral immunity. A lower proportion of circulating Tfh-like cells in HIV infected children appears to be independent of HIV treatment history and ongoing HIV viraemia and warrants further investigation.
Date Issued
2015-05-06
Date Acceptance
2015-02-26
Citation
Clinical and Experimental Immunology, 2015, 181 (1), pp.110-117
ISSN
1365-2249
Publisher
Wiley
Start Page
110
End Page
117
Journal / Book Title
Clinical and Experimental Immunology
Volume
181
Issue
1
Copyright Statement
© 2015 The Authors Clinical and Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Sponsor
National Institute for Health Research
National Institute for Health Research
Grant Number
RTF/01/009
SRF-2009-02-07
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
B cell
follicular T helper
HIV
memory
paediatric
ANTIRETROVIRAL THERAPY
ANTIBODY-RESPONSES
IMMUNE-SYSTEM
CHILDREN
MEMORY
Adolescent
Anti-Retroviral Agents
B-Lymphocyte Subsets
Child
Child, Preschool
Female
HIV Infections
Humans
Immunologic Memory
Infant
Male
Receptors, CXCR5
Receptors, Complement 3d
T-Lymphocytes, Helper-Inducer
1107 Immunology
Publication Status
Published