New manufacturing process to produce highly uniform resins with excellent performances in Solid Phase Peptide Synthesis
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Peptides are an important class of Active Pharmaceutical Ingredients. Thanks to the implementation of the solid phase synthesis methodology pioneered by the Nobel Laureate R. Bruce Merrifield in the 20th century, it is now possible to synthesize peptides with up to forty amino acids in a multi- kilogram scale. Herein, we describe a new manufacturing process to produce highly uniform resins that can be successfully applied to solid phase peptide synthesis (SPPS). The resins were employed for the synthesis of between 5 and 28mer peptides using either automatic heat-assisted microwave systems or manual mode. Excellent results are reported when PuroSynth™ CTC/S, PuroSynth™ Wang/S, PuroSynth™ Rink Amide/S and PuroSynth™ MBHA/S are used for SPPS.
Date Issued
2019-04-01
Date Acceptance
2019-03-01
Citation
Chimica Oggi/Chemistry Today, 2019, 37 (2), pp.8-10
ISSN
0392-839X
Publisher
TKS
Start Page
8
End Page
10
Journal / Book Title
Chimica Oggi/Chemistry Today
Volume
37
Issue
2
Copyright Statement
© 2019 The Author(s)
Identifier
https://www.teknoscienze.com/tks_article/new-manufacturing-process-to-produce-highly-uniform-resins-with-excellent-performances-in-solid-phase-peptide-synthesis/
Subjects
0305 Organic Chemistry
1101 Medical Biochemistry and Metabolomics
Organic Chemistry
Publication Status
Published
Date Publish Online
2019-03