Review: Circadian disruption,
chronotherapy, and deep brain stimulation
(DBS) in Parkinson's disease (PD)
chronotherapy, and deep brain stimulation
(DBS) in Parkinson's disease (PD)
File(s)
Published version (article in press)
Author(s)
Type
Journal Article
Abstract
Disruption of sleep and circadian rhythms is a pervasive symptom of Parkinson’s disease with a severe impact on quality of life. We review existing therapies for Parkinson’s disease and circadian disruption (chronotherapies), and we argue that modern deep brain stimulation technology presents a novel treatment pathway for these symptoms—it has the potential to continuously monitor and/or adaptively modulate sleep and circadian rhythms.
Date Issued
2026-08-27
Date Acceptance
2026-08-08
Citation
npj Parkinson's Disease, 2026
ISSN
2373-8057
Publisher
Nature Portfolio
Journal / Book Title
npj Parkinson's Disease
Copyright Statement
© The Author(s) 2026 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Publication Status
Published online
Date Publish Online
2026-08-27