Estrogen biosynthesis and signal transduction in ovarian disease
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Estrogen mainly binds to estrogen receptors (ERs) to regulate menstrual cycles and reproduction. The expression of ERalpha (ERα), ERbeta (ERβ), and G-protein-coupled estrogen receptor (GPER) mRNA could be detected in ovary, suggesting that they play an important role in estrogen signal transduction in ovary. And many studies have revealed that abnormal expression of estrogen and its receptors is closely related to ovarian disease or malignant tumors. With the continuous development and research of animal models, tissue-specific roles of both ERα and ERβ have been demonstrated in animals, which enable people to have a deeper understanding of the potential role of ER in regulating female reproductive diseases. Nevertheless, our current understanding of ERs expression and function in ovarian disease is, however, incomplete. To elucidate the biological mechanism behind ERs in the ovary, this review will focus on the role of ERα and ERβ in polycystic ovary syndrome (PCOS), ovarian cancer and premature ovarian failure (POF) and discuss the major challenges of existing therapies to provide a reference for the treatment of estrogen target tissue ovarian diseases.
Date Issued
2022-03-01
Date Acceptance
2022-02-03
Citation
Frontiers in Endocrinology, 2022, 13
ISSN
1664-2392
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Endocrinology
Volume
13
Copyright Statement
© 2022 Xu, Huang, Yu, Li, Fu and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not co7mply with these terms.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35299973
Subjects
ADRENAL ANDROGEN SECRETION
ALPHA GENE POLYMORPHISMS
BETA ER-BETA
biosynthesis
CANCER-CELLS
CLOMIPHENE CITRATE
DIFFERENTIAL EXPRESSION
Endocrinology & Metabolism
estrogen
estrogen receptor alpha
estrogen receptor beta
G-PROTEIN-COUPLED-RECEPTOR-30 GPR30
Life Sciences & Biomedicine
MENSTRUAL-CYCLE
MESSENGER-RNA EXPRESSION
ovary
RECEPTOR-ALPHA
Science & Technology
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
827032
Date Publish Online
2022-03-01