A Simple fMRI Compatible Robotic Stimulator to Study the Neural Mechanisms of Touch and Pain.
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Published version
Author(s)
Type
Journal Article
Abstract
This paper presents a simple device for the investigation of the human somatosensory system with functional magnetic imaging (fMRI). PC-controlled pneumatic actuation is employed to produce innocuous or noxious mechanical stimulation of the skin. Stimulation patterns are synchronized with fMRI and other relevant physiological measurements like electroencephalographic activity and vital physiological parameters. The system allows adjustable regulation of stimulation parameters and provides consistent patterns of stimulation. A validation experiment demonstrates that the system safely and reliably identifies clusters of functional activity in brain regions involved in the processing of pain. This new device is inexpensive, portable, easy-to-assemble and customizable to suit different experimental requirements. It provides robust and consistent somatosensory stimulation, which is of crucial importance to investigating the mechanisms of pain and its strong connection with the sense of touch.
Date Issued
2016-02-01
Date Acceptance
2016-01-12
Citation
Annals of Biomedical Engineering, 2016, 44 (8), pp.2431-2441
ISSN
1573-9686
Publisher
Springer Verlag (Germany)
Start Page
2431
End Page
2441
Journal / Book Title
Annals of Biomedical Engineering
Volume
44
Issue
8
Copyright Statement
© 2016 The Author(s). This article is published with open access at Springerlink.com
License URL
Sponsor
Commission of the European Communities
Commission of the European Communities
Commission of the European Communities
Commission of the European Communities
Identifier
PII: 10.1007/s10439-016-1549-y
Grant Number
PITN-GA-2012-317488
601003
611626
644727
Subjects
Mechatronics
Nervous system
Nociception
Publication Status
Published