Quantitative evaluation of beta-amyloid brain PET imaging in dementia: a comparison between two commercial software packages and the clinical report
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
OBJECTIVE: To compare commercially available image analysis tools Hermes BRASS and Siemens Syngo.VIA with clinical assessment in 18F-Florbetapir PET scans. METHODS: 225 scans were reported by clinicians and quantified using two software packages. Scans were classified into Type A (typical features) or non-Type A (atypical features) for both positive and negative scans. For BRASS, scans with z-score ≥ 2 in 2 ≥ region of interest were classed positive. For Syngo.VIA a positive scan was indicated when mean cortical standardized uptake value ratio (mcSUVR) ≥ 1.17. RESULTS: 81% scans were Type A, and 19% scans were non-Type A. The sensitivity of BRASS and Syngo.VIA for Type A scans was 98.8 and 96.3%, specificity was 73 and 92%, respectively. Sensitivity for non-Type A scans was 95.8 and 79.2%, specificity was 36.8 and 57.9%, respectively. A third threshold of identifiable levels of plaque (1.08 ≤ mcSUVR ≤ 1.17) was recommended for Syngo.VIA to increase detection of false negative scans. The false positive rate of BRASS significantly decreased when an alternative positive threshold value of mcSUVR ≥ 1.18. Introduction of alternative criteria did not improve prediction outcome for non-Type A scans. More complex solutions are recommended. CONCLUSION: Hermes criteria for a positive scan leads to a high sensitivity but a low specificity. Siemens Syngo.VIA criteria gives a high sensitivity and specificity and agrees better with the clinical report. Alternative thresholds and classifications may help to improve agreement with the clinical report. ADVANCES IN KNOWLEDGE: Software packages may assist with clinical reporting of more difficult to interpret cases that require a more experienced read.
Date Issued
2019-05-08
Date Acceptance
2019-04-11
Citation
British Journal of Radiology, 2019, 92 (1101)
ISSN
0007-1285
Publisher
British Institute of Radiology
Journal / Book Title
British Journal of Radiology
Volume
92
Issue
1101
Copyright Statement
© 2019 The Authors. Published by the British Institute of Radiology
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31017466
Subjects
Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
POSITRON-EMISSION-TOMOGRAPHY
FLORBETAPIR
Adult
Aged
Aged, 80 and over
Amyloid beta-Peptides
Brain
Dementia
Evaluation Studies as Topic
Female
Humans
Image Interpretation, Computer-Assisted
Male
Middle Aged
Neuroimaging
Positron-Emission Tomography
Sensitivity and Specificity
Brain
Humans
Dementia
Image Interpretation, Computer-Assisted
Positron-Emission Tomography
Sensitivity and Specificity
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Evaluation Studies as Topic
Amyloid beta-Peptides
Neuroimaging
Nuclear Medicine & Medical Imaging
1103 Clinical Sciences
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2019-05-08