Using technology to support management of type 1 diabetes during exercise
File(s)
Author(s)
Rilstone, Siân
Type
Thesis
Abstract
Background Uptake of exercise in people with type 1 diabetes is low despite significant health benefits. Fear of hypoglycaemia is the main barrier to exercise. Continuous glucose monitoring (CGM) with predictive alarms warning of impending hypoglycaemia may improve self-management of diabetes around exercise. Aim To assess whether an urgent low soon (ULS) alert in a CGM device affects the percentage time spent in hypoglycaemia during and after exercise, and which other variables are associated with hypoglycaemia during and after exercise. Methods After 10 days of blinded run-in (baseline), CGM was unblinded and participants randomised 1:1 to have the "urgent low soon" (ULS) alert switched 'on' or 'off' for 40 days. Participants then switched alerts 'off' or 'on' respectively for a further 40 days. Physical activity, carbohydrate and insulin doses were recorded. Results Twenty-four participants were randomised. In the 12 hours after exercise, there was no between-group difference in change from baseline in %time in hypoglycaemia in the group with ULS alert on compared to ULS off. There was no difference in change from baseline in %time <3.0 and <3.9mmol/L with the ULS on or off during the 24 hours after exercise, but with ULS alert 'on' time spent below 2.8mmol/L compared to baseline was significantly (p=0.04) lower than with ULS 'off'. Throughout the 40 days, there was a significant between-group difference in change in %time <3.0mmol/L and 2.8mmol/L in the group with the ULS alert on compared to the group with ULS alert off, favouring alert on.
Version
Open Access
Date Issued
2025-01-15
Date Awarded
2025-04-01
Copyright Statement
Attribution-ShareAlike 4.0 International (CC BY-SA)
License URL
Advisor
Oliver, Nick
Johansson, Lina
Reddy, Monika
Publisher Department
Department of Metabolism, Digestion and Reproduction
Publisher Institution
Imperial College London
Qualification Level
Doctoral
Qualification Name
Doctor of Philosophy (PhD)