mprovements in survivalandchanging patternsof transmission mean thatthe population
of people living with HIV (PLWH) is ageing. Increasing age is a risk factor for many
varieties of cancer, including most non-AIDS-defining malignancies. Moreover, the
premature ageing described in PLWH and the development of cancer share many
molecular features. As a consequence, there has been a dramatic increase in the number
of PLWH who are diagnosed with cancer. The treatment of older HIV-positive patients
with cancer requires careful attention to details. It is particularly important to take into
account comorbidities, pharmacological drug interactions, and opportunistic infection
prophylaxiswhendecidingonclinicalmanagementforthesepatients.Thus,cancerinthe
ageing population living with HIV poses many challenges for both HIV physicians and
oncologists.